Studies on Aminopterin, Leucovorin and Folacin with the Chick

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A Phase 1 study of high doses of aminopterin with leucovorin rescue in patients with advanced metastatic tumors.

We have conducted a Phase 1 study of aminopterin (AMT) with leucovorin (LV) in 17 patients. AMT was administered by bolus injection every 7 to 14 days in dosages from 25 to 425 mg/sq m. LV rescue was instituted at 24 hr and continued for 48 to 72 hr. At dosages above 50 mg/sq m, we observed nephrotoxicity defined as greater than or equal to a 25% increase in serum creatinine 24 hr after AMT adm...

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ژورنال

عنوان ژورنال: Poultry Science

سال: 1954

ISSN: 0032-5791

DOI: 10.3382/ps.0330107